NEUROINFLAMMATION AS A TARGET FOR GLAUCOMA THERAPY

Neuroinflammation as a target for glaucoma therapy

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy.Indeed, inflammation - involving the activation and proliferation of resident glial teal horse blanket cells (astrocytes, Muller

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Deciphering the Mechanism of Gilteritinib Overcoming Lorlatinib Resistance to the Double Mutant I1171N/F1174I in Anaplastic Lymphoma Kinase

Anaplastic lymphoma kinase (ALK) is validated as a therapeutic molecular target in multiple malignancies, such as non-small cell lung cancer (NSCLC).However, the feasibility of targeted therapies exerted by ALK inhibitors is inevitably hindered owing to drug resistance.The emergence of clinically acquired drug mutations has become a major challenge

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